Lactase, sucrase, maltase, and palatinase (in lieu of isomaltase) activities can be determined from an intestinal biopsy weighing approximately 5 mg wet weight. The enzyme activities are determined in small bowel biopsies taken via endoscope by the referring clinical physician.
Determination of pancreatic enzyme activities (amylase, chymotrypsin, lipase, and trypsin) in duodenal secretions, usually in conjunction with a secretin stimulation test performed by the referring physician.
Pancreatic elastase (PE) is not degraded during intestinal transit and the concentration of PE in a stool sample reflects exocrine pancreatic function. This assay allows the diagnosis or exclusion of pancreatic exocrine insufficiency, which can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumor, cholelithiasis or diabetes mellitus.
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